Pesquisa
Apiguaco® Cough Syrup is an herbal medicine made from standardized Mikania glomerata extract, standardized at 1.46 mg/g of coumarin. It also has honey in its composition.
This medication is an expectorant syrup that helps eliminate mucus in persistent coughs cases. Additionally, this medication has bronchodilator activity, being indicated for the relief of bronchial spasm associated with asthma attacks, chronic bronchitis, and emphysema.
| IF SYMPTOMS PERSIST, THE DOCTOR SHALL BE CONSULTED. |
APIGUACO® - COUGH SYRUP 150 ml - Mikania glomerata - Registration with the Ministry of Health: 1.2107.0009.001 6. Indications: APIGUACO® - COUGH SYRUP This medication is an expectorant syrup that helps eliminate mucus in persistent coughs cases. Additionally, this medication has bronchodilator activity, being indicated for the relief of bronchial spasm associated with asthma attacks, chronic bronchitis and emphysema. APIGUACO® - COUGH SYRUP IS A MEDICATION. THE USE OF THIS PRODUCT HAS INHERENT RISKS. CONSULT YOUR PHYSICIAN AND PHARMACIST. READ THE PRODUCT PACKAGE INSERT.
Each 10 ml of the product contains: 1 g of guaco (Mikania glomerata)* standardized extract. Excipient: honey, potassium sorbate, and liquid invert sugar.
(*) Standardized at 1.46 mg/g of coumarin.
Each measuring cup (10 ml) contains 1.46 mg of coumarin.
IMPORTANT INFORMATION
Oral administration. Adult and pediatric use above 2 years old
Follow the instructions of use strictly. If symptoms persist, seek medical advice.
Store at room temperature (15 to 30°C), in a place protected from light and moisture.
Registered product based on traditional use, not recommended for long-term use.
Attention diabetics: contains sugar
| Each 10.0 ml of this product contains: | ||
| Standardized extract Mikania glomerata (*) | 1,0 g | |
| Excipient (**) | 10,0 ml | |
| Each 10.0 ml contains 1.46 mg of coumarin | ||
(*) Standardized at 1.46 mg/g coumarin.
(**) Honey, potassium sorbate and liquid invert sugar.
Apiguaco® Honey Cough Syrup has a greenish-yellow color and considerable viscosity. Before using, observe the appearance of the product. If it is in its expiration date and you notice any changes in the aspect, consult the pharmacist to see if you can use it. This product should be kept out of the reach of children.
It can be consumed directly with the 10-mL measuring cup (1.46 mg of coumarin/10 mL measuring cup) or a tablespoon, according to the dosage described below. We recommend shaking the bottle before use.
Adults: Except at medical discretion, it is recommended to take 10 mL (1 measuring cup), 3 times a day (equivalent to 1.46 mg of coumarin per dose or 4.38 mg of coumarin/day), with 8-hour intervals between doses.
Pediatric Use (above 2 years old): Except at medical discretion, it is recommended to take 0.5 mL/kg/day, divided into 3 doses a day, at 8-hour intervals, as shown in the table below, indicating the amount per intake and per day:
| Weight Child | Dosage/ taken | Dosage/ day | Child Body Weight | Dosage/ taken | Dosage/ day |
| 4,0 kg | 0,67 ml | 2,0 ml/day | 18,0 kg | 3,00 ml | 9,0 ml/day |
| 5,0 kg | 0,84 ml | 2,5 ml/day | 19,0 kg | 3,16 ml | 9,5 ml/day |
| 6,0 kg | 1,00 ml | 3,0 ml/day | 20,0 kg | 3,33 ml | 10,0 ml/day |
| 7,0 kg | 1,17 ml | 3,5 ml/day | 21,0 kg | 3,50 ml | 10,5 ml/day |
| 8,0 kg | 1,34 ml | 4,0 ml/day | 22,0 kg | 3,67 ml | 11,0 ml/day |
| 9,0 kg | 1,50 ml | 4,5 ml/day | 23,0 kg | 3,84 ml | 11,5 ml/day |
| 10,0 kg | 1,67 ml | 5,0 ml/day | 24,0 kg | 4,00 ml | 12,0 ml/day |
| 11,0 kg | 1,84 ml | 5,5 ml/day | 25,0 kg | 4,17 ml | 12,5 ml/day |
| 12,0 kg | 2,00 ml | 6,0 ml/day | 26,0 kg | 4,34 ml | 13,0 ml/day |
| 13,0 kg | 2,17 ml | 6,5 ml/day | 27,0 kg | 4,50 ml | 13,5 ml/day |
| 14,0 kg | 2,34 ml | 7,0 ml/day | 28,0 kg | 4,67 ml | 14,0 ml/day |
| 15,0 kg | 2,50 ml | 7,5 ml/day | 29,0 kg | 4,84 ml | 14,5 ml/day |
| 16,0 kg | 2,67 ml | 8,0 ml/day | 30,0 kg | 5,00 ml | 15,0 ml/day |
| 17,0 kg | 2,84 ml | 8,5 ml/day | |||
The total treatment time is variable. For cases of acute respiratory disorders, treatment for 7 days is suggested, and up to two weeks in case of chronic conditions.
The maximum daily intake recommendation is 3 10-mL measuring cups or 3 tablespoons a day, corresponding to 4.38 mg of coumarin/day.
The therapeutic dosage, as determined based on ANVISA’s list of simplified registration of herbal medicines (IN n. 5, 12/11/2008), is 0.50 mg to 5.0 mg of coumarin/day, which is equivalent to the concentration of 8.33 μg to 83.0 μg/kg/day, considering an average adult weight of 60.0 kg. Thus, considering that the concentration of coumarin/mL of syrup is 146 μg, a dosage of 0.5 mL/kg/day of APIGUACO® HONEY COUGH SYRUP is suggested.
Follow the instructions of use strictly. If you have any questions about this product, seek advice from your pharmacist. If symptoms persist, seek medical advice.
This medication is an expectorant syrup that helps eliminate mucus in persistent coughs cases. Additionally, this medication has bronchodilator activity, being indicated for the relief of bronchial spasm associated with asthma attacks, chronic bronchitis, and emphysema.
The therapeutic properties of guaco (Mikania glomerata) include bronchi dilation (bronchodilator action) and elimination of respiratory secretions.
The expectorant activity of this medication occurs because guaco fluidifies the mucus, making it less viscous and “looser”. This way, the mucus can be expelled more easily. Additionally, it reduces the production of bronchial secretions.
Guaco also acts as a bronchodilator, by relaxing the bronchi muscles to help open the airways and make it easier for the air to get in and out of the lungs. This reduces chest “tightness” and “wheezing”, helping you breathe easier.
Patients with a history of hypersensitivity and allergy to any of the formula component.
Patients with a history of hypersensitivity to Mikania glomerata extract or any other plants of Asteraceae family.
This product is contraindicated for children under 2 years old.
Pregnant and lactating women should not use the product, with medical guidance only.
Note for diabetic patients: this product contains sugar.
Original from South America, guaco (Mikania glomerata) is found throughout Brazil. It has known beneficial effects on the respiratory system.
Coumarin, and essential oils, such as kaurenoic, grandifloric, cinnamoylgrandifloric and kaurenol acids, are some of the substances of its composition. Additionally, it contains β-sitosterol, friedelin, stigmasterol, hydrolysable tannins, flavonoids and saponin.
Studies have reported that guaco causes bronchodilation and relaxation of the respiratory smooth muscles, followed by anti-inflammatory and antiallergic activities, which are extremely beneficial in the treatment of asthma and other respiratory diseases.
Honey is a natural sweet substance produced by bees from floral nectar and sugary secretions from other parts of plants.
It is composed of approximately 75 – 80% carbohydrates, 0.38% proteins, 0.1% acids from fruits and 0.2% minerals. In addition to its nutritional properties, honey provides sedative and emollient effects.
